A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci
Identifieur interne : 000509 ( Main/Exploration ); précédent : 000508; suivant : 000510A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci
Auteurs : Yosr Hamdi ; Mariem Ben Rekaya ; Shan Jingxuan [Qatar] ; Majdi Nagara ; Olfa Messaoud ; Amel Benammar Elgaaied [Tunisie] ; Ridha Mrad [Tunisie] ; Lotfi Chouchane [Qatar] ; Mohamed Samir Boubaker ; Sonia Abdelhak ; Hamouda Boussen [Tunisie] ; Lilia Romdhane [Tunisie]Source :
- BMC Cancer [ 1471-2407 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Déséquilibre de liaison (génétique), Femelle (MeSH), Fréquence d'allèle (génétique), Haplotypes (génétique), Humains (MeSH), Locus génétiques (génétique), Mâle (MeSH), Polymorphisme de nucléotide simple (MeSH), Population d'origine africaine (génétique), Prédisposition génétique à une maladie (MeSH), Simulation numérique (MeSH), Tumeurs du sein (génétique), Tunisie (MeSH), Volontaires sains (MeSH), Étude d'association pangénomique (MeSH).
- MESH :
- génétique : Déséquilibre de liaison, Fréquence d'allèle, Haplotypes, Locus génétiques, Population d'origine africaine, Tumeurs du sein.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Simulation numérique, Tunisie, Volontaires sains, Étude d'association pangénomique.
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- Adult (MeSH), African Continental Ancestry Group (genetics), Breast Neoplasms (genetics), Computer Simulation (MeSH), Female (MeSH), Gene Frequency (genetics), Genetic Loci (genetics), Genetic Predisposition to Disease (MeSH), Genome-Wide Association Study (MeSH), Haplotypes (genetics), Healthy Volunteers (MeSH), Humans (MeSH), Linkage Disequilibrium (genetics), Male (MeSH), Middle Aged (MeSH), Polymorphism, Single Nucleotide (MeSH), Tunisia (MeSH).
- MESH :
- geographic : Tunisia.
- genetics : African Continental Ancestry Group, Breast Neoplasms, Gene Frequency, Genetic Loci, Haplotypes, Linkage Disequilibrium.
- Adult, Computer Simulation, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Healthy Volunteers, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide.
Abstract
Breast cancer is the most common cancer in women worldwide. Around 50% of breast cancer familial risk has been so far explained by known susceptibility alleles with variable levels of risk and prevalence. The vast majority of these breast cancer associated variations reported to date are from populations of European ancestry. In spite of its heterogeneity and genetic wealth, North-African populations have not been studied by the HapMap and the 1000Genomes projects. Thus, very little is known about the genetic architecture of these populations.
This study aimed to investigate a subset of common breast cancer loci in the general Tunisian population and to compare their genetic composition to those of other ethnic groups. We undertook a genome-wide haplotype study by genotyping 135 Tunisian subjects using the Affymetrix 6.0-Array. We compared Tunisian allele frequencies and linkage disequilibrium patterns to those of HapMap populations and we performed a comprehensive assessment of the functional effects of several selected variants.
Haplotype analyses showed that at risk haplotypes on 2p24, 4q21, 6q25, 9q31, 10q26, 11p15, 11q13 and 14q32 loci are considerably frequent in the Tunisian population (> 20%). Allele frequency comparison showed that the frequency of rs13329835 is significantly different between Tunisian and all other HapMap populations. LD-blocks and Principle Component Analysis revealed that the genetic characteristics of breast cancer variants in the Tunisian, and so probably the North-African populations, are more similar to those of Europeans than Africans.
Using eQTl analysis, we characterized rs9911630 as the most strongly expression-associated SNP that seems to affect the expression levels of
We illustrated the utility of combining haplotype analysis in diverse ethnic groups with functional analysis to explore breast cancer genetic architecture in Tunisia. Results presented in this study provide the first report on a large number of common breast cancer genetic polymorphisms in the Tunisian population which may establish a baseline database to guide future association studies in North Africa.
The online version of this article (10.1186/s12885-018-5133-8) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12885-018-5133-8
PubMed: 30594178
PubMed Central: 6310952
Affiliations:
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id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2298 7385</institution-id><institution-id institution-id-type="GRID">grid.418517.e</institution-id><institution>Laboratory of biomedical genomics and oncogenetics,</institution><institution>Institut Pasteur de Tunis, Université Tunis El Manar,</institution></institution-wrap>13, Place Pasteur BP 74, 1002 Tunis, Belvédère Tunisie</nlm:aff><wicri:noCountry code="subfield">Belvédère Tunisie</wicri:noCountry></affiliation></author><author><name sortKey="Benammar Elgaaied, Amel" sort="Benammar Elgaaied, Amel" uniqKey="Benammar Elgaaied A" first="Amel" last="Benammar Elgaaied">Amel Benammar Elgaaied</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000000122959819</institution-id><institution-id institution-id-type="GRID">grid.12574.35</institution-id><institution>Laboratory of Genetics, Immunology and Human Pathology, Department of Biology, Faculty of Sciences of Tunis,</institution><institution>University of Tunis El Manar,</institution></institution-wrap>Tunis, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Tunis</wicri:regionArea></affiliation></author><author><name sortKey="Mrad, Ridha" sort="Mrad, Ridha" uniqKey="Mrad R" first="Ridha" last="Mrad">Ridha Mrad</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0594 6356</institution-id><institution-id institution-id-type="GRID">grid.413827.b</institution-id><institution>Department of Human Genetics,</institution><institution>Charles Nicolle Hospital,</institution></institution-wrap>Tunis, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Tunis</wicri:regionArea></affiliation></author><author><name sortKey="Chouchane, Lotfi" sort="Chouchane, Lotfi" uniqKey="Chouchane L" first="Lotfi" last="Chouchane">Lotfi Chouchane</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0582 4340</institution-id><institution-id institution-id-type="GRID">grid.416973.e</institution-id><institution>Department of Genetic Medicine,</institution><institution>Weill Cornell Medical College-Qatar,</institution></institution-wrap>Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Doha</wicri:regionArea></affiliation></author><author><name sortKey="Boubaker, Mohamed Samir" sort="Boubaker, Mohamed Samir" uniqKey="Boubaker M" first="Mohamed Samir" last="Boubaker">Mohamed Samir Boubaker</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2298 7385</institution-id><institution-id institution-id-type="GRID">grid.418517.e</institution-id><institution>Laboratory of biomedical genomics and oncogenetics,</institution><institution>Institut Pasteur de Tunis, Université Tunis El Manar,</institution></institution-wrap>13, Place Pasteur BP 74, 1002 Tunis, Belvédère Tunisie</nlm:aff><wicri:noCountry code="subfield">Belvédère Tunisie</wicri:noCountry></affiliation></author><author><name sortKey="Abdelhak, Sonia" sort="Abdelhak, Sonia" uniqKey="Abdelhak S" first="Sonia" last="Abdelhak">Sonia Abdelhak</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2298 7385</institution-id><institution-id institution-id-type="GRID">grid.418517.e</institution-id><institution>Laboratory of biomedical genomics and oncogenetics,</institution><institution>Institut Pasteur de Tunis, Université Tunis El Manar,</institution></institution-wrap>13, Place Pasteur BP 74, 1002 Tunis, Belvédère Tunisie</nlm:aff><wicri:noCountry code="subfield">Belvédère Tunisie</wicri:noCountry></affiliation></author><author><name sortKey="Boussen, Hamouda" sort="Boussen, Hamouda" uniqKey="Boussen H" first="Hamouda" last="Boussen">Hamouda Boussen</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.413207.3</institution-id><institution>Medical Oncology Department,</institution><institution>Abderrahmen Mami Hospital,</institution></institution-wrap>Ariana, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Ariana</wicri:regionArea></affiliation></author><author><name sortKey="Romdhane, Lilia" sort="Romdhane, Lilia" uniqKey="Romdhane L" first="Lilia" last="Romdhane">Lilia Romdhane</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2298 7385</institution-id><institution-id institution-id-type="GRID">grid.418517.e</institution-id><institution>Laboratory of biomedical genomics and oncogenetics,</institution><institution>Institut Pasteur de Tunis, Université Tunis El Manar,</institution></institution-wrap>13, Place Pasteur BP 74, 1002 Tunis, Belvédère Tunisie</nlm:aff><wicri:noCountry code="subfield">Belvédère Tunisie</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.442618.d</institution-id><institution>Department of Biology, Faculty of Science of Bizerte,</institution><institution>Université Tunis Carthage,</institution></institution-wrap>Tunis, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Tunis</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Cancer</title><idno type="eISSN">1471-2407</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>African Continental Ancestry Group (genetics)</term><term>Breast Neoplasms (genetics)</term><term>Computer Simulation (MeSH)</term><term>Female (MeSH)</term><term>Gene Frequency (genetics)</term><term>Genetic Loci (genetics)</term><term>Genetic Predisposition to Disease (MeSH)</term><term>Genome-Wide Association Study (MeSH)</term><term>Haplotypes (genetics)</term><term>Healthy Volunteers (MeSH)</term><term>Humans (MeSH)</term><term>Linkage Disequilibrium (genetics)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Polymorphism, Single Nucleotide (MeSH)</term><term>Tunisia (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Déséquilibre de liaison (génétique)</term><term>Femelle (MeSH)</term><term>Fréquence d'allèle (génétique)</term><term>Haplotypes (génétique)</term><term>Humains (MeSH)</term><term>Locus génétiques (génétique)</term><term>Mâle (MeSH)</term><term>Polymorphisme de nucléotide simple (MeSH)</term><term>Population d'origine africaine (génétique)</term><term>Prédisposition génétique à une maladie (MeSH)</term><term>Simulation numérique (MeSH)</term><term>Tumeurs du sein (génétique)</term><term>Tunisie (MeSH)</term><term>Volontaires sains (MeSH)</term><term>Étude d'association pangénomique (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Tunisia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>African Continental Ancestry Group</term><term>Breast Neoplasms</term><term>Gene Frequency</term><term>Genetic Loci</term><term>Haplotypes</term><term>Linkage Disequilibrium</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Déséquilibre de liaison</term><term>Fréquence d'allèle</term><term>Haplotypes</term><term>Locus génétiques</term><term>Population d'origine africaine</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Computer Simulation</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Healthy Volunteers</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Simulation numérique</term><term>Tunisie</term><term>Volontaires sains</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Breast cancer is the most common cancer in women worldwide. Around 50% of breast cancer familial risk has been so far explained by known susceptibility alleles with variable levels of risk and prevalence. The vast majority of these breast cancer associated variations reported to date are from populations of European ancestry. In spite of its heterogeneity and genetic wealth, North-African populations have not been studied by the HapMap and the 1000Genomes projects. Thus, very little is known about the genetic architecture of these populations.</p></sec><sec><title>Methods</title><p id="Par2">This study aimed to investigate a subset of common breast cancer loci in the general Tunisian population and to compare their genetic composition to those of other ethnic groups. We undertook a genome-wide haplotype study by genotyping 135 Tunisian subjects using the Affymetrix 6.0-Array. We compared Tunisian allele frequencies and linkage disequilibrium patterns to those of HapMap populations and we performed a comprehensive assessment of the functional effects of several selected variants.</p></sec><sec><title>Results</title><p id="Par3">Haplotype analyses showed that at risk haplotypes on 2p24, 4q21, 6q25, 9q31, 10q26, 11p15, 11q13 and 14q32 loci are considerably frequent in the Tunisian population (> 20%). Allele frequency comparison showed that the frequency of rs13329835 is significantly different between Tunisian and all other HapMap populations. LD-blocks and Principle Component Analysis revealed that the genetic characteristics of breast cancer variants in the Tunisian, and so probably the North-African populations, are more similar to those of Europeans than Africans.</p><p id="Par4">Using eQTl analysis, we characterized rs9911630 as the most strongly expression-associated SNP that seems to affect the expression levels of <italic>BRCA1</italic> and two long non coding RNAs (<italic>NBR2</italic> and <italic>LINC008854</italic>). Additional <italic>in-silico</italic> analysis also suggested a potential functional significance of this variant.</p></sec><sec><title>Conclusions</title><p id="Par5">We illustrated the utility of combining haplotype analysis in diverse ethnic groups with functional analysis to explore breast cancer genetic architecture in Tunisia. Results presented in this study provide the first report on a large number of common breast cancer genetic polymorphisms in the Tunisian population which may establish a baseline database to guide future association studies in North Africa.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (10.1186/s12885-018-5133-8) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sinha, R" uniqKey="Sinha R">R Sinha</name></author><author><name sortKey="Coyle, C" uniqKey="Coyle C">C Coyle</name></author><author><name sortKey="Ring, A" uniqKey="Ring A">A Ring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghoussaini, M" uniqKey="Ghoussaini M">M Ghoussaini</name></author><author><name sortKey="Pharoah, Pd" uniqKey="Pharoah P">PD Pharoah</name></author><author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feunteun, J" uniqKey="Feunteun J">J Feunteun</name></author><author><name sortKey="Lenoir, Gm" uniqKey="Lenoir G">GM Lenoir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miki, Y" uniqKey="Miki Y">Y Miki</name></author><author><name sortKey="Swensen, J" uniqKey="Swensen J">J Swensen</name></author><author><name sortKey="Shattuck Eidens, D" uniqKey="Shattuck Eidens D">D Shattuck-Eidens</name></author><author><name sortKey="Futreal, Pa" uniqKey="Futreal P">PA Futreal</name></author><author><name sortKey="Harshman, K" uniqKey="Harshman K">K Harshman</name></author><author><name sortKey="Tavtigian, S" uniqKey="Tavtigian S">S Tavtigian</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Cochran, C" uniqKey="Cochran C">C Cochran</name></author><author><name sortKey="Bennett, Lm" uniqKey="Bennett L">LM Bennett</name></author><author><name sortKey="Ding, W" uniqKey="Ding W">W Ding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name></author><author><name sortKey="Simard, J" uniqKey="Simard J">J Simard</name></author><author><name sortKey="Rommens, J" uniqKey="Rommens J">J Rommens</name></author><author><name sortKey="Couch, F" uniqKey="Couch F">F Couch</name></author><author><name sortKey="Shattuck Eidens, D" uniqKey="Shattuck Eidens D">D Shattuck-Eidens</name></author><author><name sortKey="Neuhausen, S" uniqKey="Neuhausen S">S Neuhausen</name></author><author><name sortKey="Merajver, S" uniqKey="Merajver S">S Merajver</name></author><author><name sortKey="Thorlacius, S" uniqKey="Thorlacius S">S Thorlacius</name></author><author><name sortKey="Offit, K" uniqKey="Offit K">K Offit</name></author><author><name sortKey="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D">D Stoppa-Lyonnet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wooster, R" uniqKey="Wooster R">R Wooster</name></author><author><name sortKey="Bignell, G" uniqKey="Bignell G">G Bignell</name></author><author><name sortKey="Lancaster, J" uniqKey="Lancaster J">J Lancaster</name></author><author><name sortKey="Swift, S" uniqKey="Swift S">S Swift</name></author><author><name sortKey="Seal, S" uniqKey="Seal S">S Seal</name></author><author><name sortKey="Mangion, J" uniqKey="Mangion J">J Mangion</name></author><author><name sortKey="Collins, N" uniqKey="Collins N">N Collins</name></author><author><name sortKey="Gregory, S" uniqKey="Gregory S">S Gregory</name></author><author><name sortKey="Gumbs, C" uniqKey="Gumbs C">C Gumbs</name></author><author><name sortKey="Micklem, G" uniqKey="Micklem G">G Micklem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borresen, Al" uniqKey="Borresen A">AL Borresen</name></author><author><name sortKey="Andersen, Ti" uniqKey="Andersen T">TI Andersen</name></author><author><name sortKey="Garber, J" uniqKey="Garber J">J Garber</name></author><author><name sortKey="Barbier Piraux, N" uniqKey="Barbier Piraux N">N Barbier-Piraux</name></author><author><name sortKey="Thorlacius, S" uniqKey="Thorlacius S">S Thorlacius</name></author><author><name sortKey="Eyfjord, J" uniqKey="Eyfjord J">J Eyfjord</name></author><author><name sortKey="Ottestad, L" uniqKey="Ottestad L">L Ottestad</name></author><author><name sortKey="Smith Sorensen, B" uniqKey="Smith Sorensen B">B Smith-Sorensen</name></author><author><name sortKey="Hovig, E" uniqKey="Hovig E">E Hovig</name></author><author><name sortKey="Malkin, D" uniqKey="Malkin D">D Malkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venkateshwari, A" uniqKey="Venkateshwari A">A Venkateshwari</name></author><author><name sortKey="Clark, Dw" uniqKey="Clark D">DW Clark</name></author><author><name sortKey="Nallari, P" uniqKey="Nallari P">P Nallari</name></author><author><name sortKey="Vinod, C" uniqKey="Vinod C">C Vinod</name></author><author><name sortKey="Kumarasamy, T" uniqKey="Kumarasamy T">T Kumarasamy</name></author><author><name sortKey="Reddy, G" uniqKey="Reddy G">G Reddy</name></author><author><name sortKey="Jyothy, A" uniqKey="Jyothy A">A Jyothy</name></author><author><name sortKey="Kumar, Mv" uniqKey="Kumar M">MV Kumar</name></author><author><name sortKey="Ramaiyer, R" uniqKey="Ramaiyer R">R Ramaiyer</name></author><author><name sortKey="Palle, K" uniqKey="Palle K">K Palle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Ph" uniqKey="Lin P">PH Lin</name></author><author><name sortKey="Kuo, Wh" uniqKey="Kuo W">WH Kuo</name></author><author><name sortKey="Huang, Ac" uniqKey="Huang A">AC Huang</name></author><author><name sortKey="Lu, Ys" uniqKey="Lu Y">YS Lu</name></author><author><name sortKey="Lin, Ch" uniqKey="Lin C">CH Lin</name></author><author><name sortKey="Kuo, Sh" uniqKey="Kuo S">SH Kuo</name></author><author><name sortKey="Wang, My" uniqKey="Wang M">MY Wang</name></author><author><name sortKey="Liu, Cy" uniqKey="Liu C">CY Liu</name></author><author><name sortKey="Cheng, Ft" uniqKey="Cheng F">FT Cheng</name></author><author><name sortKey="Yeh, Mh" uniqKey="Yeh M">MH Yeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, Lp" uniqKey="Ren L">LP Ren</name></author><author><name sortKey="Xian, Ys" uniqKey="Xian Y">YS Xian</name></author><author><name sortKey="Diao, Dm" uniqKey="Diao D">DM Diao</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Guo, Q" uniqKey="Guo Q">Q Guo</name></author><author><name sortKey="Dang, Cx" uniqKey="Dang C">CX Dang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meijers Heijboer, H" uniqKey="Meijers Heijboer H">H Meijers-Heijboer</name></author><author><name sortKey="Wijnen, J" uniqKey="Wijnen J">J Wijnen</name></author><author><name sortKey="Vasen, H" uniqKey="Vasen H">H Vasen</name></author><author><name sortKey="Wasielewski, M" uniqKey="Wasielewski M">M Wasielewski</name></author><author><name sortKey="Wagner, A" uniqKey="Wagner A">A Wagner</name></author><author><name sortKey="Hollestelle, A" uniqKey="Hollestelle A">A Hollestelle</name></author><author><name sortKey="Elstrodt, F" uniqKey="Elstrodt F">F Elstrodt</name></author><author><name sortKey="Van Den Bos, R" uniqKey="Van Den Bos R">R van den Bos</name></author><author><name sortKey="De Snoo, A" uniqKey="De Snoo A">A de Snoo</name></author><author><name sortKey="Fat, Gt" uniqKey="Fat G">GT Fat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Calvez Kelm, F" uniqKey="Le Calvez Kelm F">F Le Calvez-Kelm</name></author><author><name sortKey="Lesueur, F" uniqKey="Lesueur F">F Lesueur</name></author><author><name sortKey="Damiola, F" uniqKey="Damiola F">F Damiola</name></author><author><name sortKey="Vallee, M" uniqKey="Vallee M">M Vallee</name></author><author><name sortKey="Voegele, C" uniqKey="Voegele C">C Voegele</name></author><author><name sortKey="Babikyan, D" uniqKey="Babikyan D">D Babikyan</name></author><author><name sortKey="Durand, G" uniqKey="Durand G">G Durand</name></author><author><name sortKey="Forey, N" uniqKey="Forey N">N Forey</name></author><author><name sortKey="Mckay Chopin, S" uniqKey="Mckay Chopin S">S McKay-Chopin</name></author><author><name sortKey="Robinot, N" uniqKey="Robinot N">N Robinot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renwick, A" uniqKey="Renwick A">A Renwick</name></author><author><name sortKey="Thompson, D" uniqKey="Thompson D">D Thompson</name></author><author><name sortKey="Seal, S" uniqKey="Seal S">S Seal</name></author><author><name sortKey="Kelly, P" uniqKey="Kelly P">P Kelly</name></author><author><name sortKey="Chagtai, T" uniqKey="Chagtai T">T Chagtai</name></author><author><name sortKey="Ahmed, M" uniqKey="Ahmed M">M Ahmed</name></author><author><name sortKey="North, B" uniqKey="North B">B North</name></author><author><name sortKey="Jayatilake, H" uniqKey="Jayatilake H">H Jayatilake</name></author><author><name sortKey="Barfoot, R" uniqKey="Barfoot R">R Barfoot</name></author><author><name sortKey="Spanova, K" uniqKey="Spanova K">K Spanova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name></author><author><name sortKey="Oefner, Pj" uniqKey="Oefner P">PJ Oefner</name></author><author><name sortKey="Babikyan, D" uniqKey="Babikyan D">D Babikyan</name></author><author><name sortKey="Hartmann, A" uniqKey="Hartmann A">A Hartmann</name></author><author><name sortKey="Healey, S" uniqKey="Healey S">S Healey</name></author><author><name sortKey="Le Calvez Kelm, F" uniqKey="Le Calvez Kelm F">F Le Calvez-Kelm</name></author><author><name sortKey="Lesueur, F" uniqKey="Lesueur F">F Lesueur</name></author><author><name sortKey="Byrnes, Gb" uniqKey="Byrnes G">GB Byrnes</name></author><author><name sortKey="Chuang, Sc" uniqKey="Chuang S">SC Chuang</name></author><author><name sortKey="Forey, N" uniqKey="Forey N">N Forey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erkko, H" uniqKey="Erkko H">H Erkko</name></author><author><name sortKey="Xia, B" uniqKey="Xia B">B Xia</name></author><author><name sortKey="Nikkila, J" uniqKey="Nikkila J">J Nikkila</name></author><author><name sortKey="Schleutker, J" uniqKey="Schleutker J">J Schleutker</name></author><author><name sortKey="Syrjakoski, K" uniqKey="Syrjakoski K">K Syrjakoski</name></author><author><name sortKey="Mannermaa, A" uniqKey="Mannermaa A">A Mannermaa</name></author><author><name sortKey="Kallioniemi, A" uniqKey="Kallioniemi A">A Kallioniemi</name></author><author><name sortKey="Pylkas, K" uniqKey="Pylkas K">K Pylkas</name></author><author><name sortKey="Karppinen, Sm" uniqKey="Karppinen S">SM Karppinen</name></author><author><name sortKey="Rapakko, K" uniqKey="Rapakko K">K Rapakko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, A" uniqKey="Cox A">A Cox</name></author><author><name sortKey="Dunning, Am" uniqKey="Dunning A">AM Dunning</name></author><author><name sortKey="Garcia Closas, M" uniqKey="Garcia Closas M">M Garcia-Closas</name></author><author><name sortKey="Balasubramanian, S" uniqKey="Balasubramanian S">S Balasubramanian</name></author><author><name sortKey="Reed, Mw" uniqKey="Reed M">MW Reed</name></author><author><name sortKey="Pooley, Ka" uniqKey="Pooley K">KA Pooley</name></author><author><name sortKey="Scollen, S" uniqKey="Scollen S">S Scollen</name></author><author><name sortKey="Baynes, C" uniqKey="Baynes C">C Baynes</name></author><author><name sortKey="Ponder, Ba" uniqKey="Ponder B">BA Ponder</name></author><author><name sortKey="Chanock, S" uniqKey="Chanock S">S Chanock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Easton, Df" uniqKey="Easton D">DF Easton</name></author><author><name sortKey="Pooley, Ka" uniqKey="Pooley K">KA Pooley</name></author><author><name sortKey="Dunning, Am" uniqKey="Dunning A">AM Dunning</name></author><author><name sortKey="Pharoah, Pd" uniqKey="Pharoah P">PD Pharoah</name></author><author><name sortKey="Thompson, D" uniqKey="Thompson D">D Thompson</name></author><author><name sortKey="Ballinger, Dg" uniqKey="Ballinger D">DG Ballinger</name></author><author><name sortKey="Struewing, Jp" uniqKey="Struewing J">JP Struewing</name></author><author><name sortKey="Morrison, J" uniqKey="Morrison J">J Morrison</name></author><author><name sortKey="Field, H" uniqKey="Field H">H Field</name></author><author><name sortKey="Luben, R" uniqKey="Luben R">R Luben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunter, Dj" uniqKey="Hunter D">DJ Hunter</name></author><author><name sortKey="Kraft, P" uniqKey="Kraft P">P Kraft</name></author><author><name sortKey="Jacobs, Kb" uniqKey="Jacobs K">KB Jacobs</name></author><author><name sortKey="Cox, Dg" uniqKey="Cox D">DG Cox</name></author><author><name sortKey="Yeager, M" uniqKey="Yeager M">M Yeager</name></author><author><name sortKey="Hankinson, Se" uniqKey="Hankinson S">SE Hankinson</name></author><author><name sortKey="Wacholder, S" uniqKey="Wacholder S">S Wacholder</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Welch, R" uniqKey="Welch R">R Welch</name></author><author><name sortKey="Hutchinson, A" uniqKey="Hutchinson A">A Hutchinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacey, Sn" uniqKey="Stacey S">SN Stacey</name></author><author><name sortKey="Manolescu, A" uniqKey="Manolescu A">A Manolescu</name></author><author><name sortKey="Sulem, P" uniqKey="Sulem P">P Sulem</name></author><author><name sortKey="Thorlacius, S" uniqKey="Thorlacius S">S Thorlacius</name></author><author><name sortKey="Gudjonsson, Sa" uniqKey="Gudjonsson S">SA Gudjonsson</name></author><author><name sortKey="Jonsson, Gf" uniqKey="Jonsson G">GF Jonsson</name></author><author><name sortKey="Jakobsdottir, M" uniqKey="Jakobsdottir M">M Jakobsdottir</name></author><author><name sortKey="Bergthorsson, Jt" uniqKey="Bergthorsson J">JT Bergthorsson</name></author><author><name sortKey="Gudmundsson, J" uniqKey="Gudmundsson J">J Gudmundsson</name></author><author><name sortKey="Aben, Kk" uniqKey="Aben K">KK Aben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S Ahmed</name></author><author><name sortKey="Thomas, G" uniqKey="Thomas G">G Thomas</name></author><author><name sortKey="Ghoussaini, M" uniqKey="Ghoussaini M">M Ghoussaini</name></author><author><name sortKey="Healey, Cs" uniqKey="Healey C">CS Healey</name></author><author><name sortKey="Humphreys, Mk" uniqKey="Humphreys M">MK Humphreys</name></author><author><name sortKey="Platte, R" uniqKey="Platte R">R Platte</name></author><author><name sortKey="Morrison, J" uniqKey="Morrison J">J Morrison</name></author><author><name sortKey="Maranian, M" uniqKey="Maranian M">M Maranian</name></author><author><name sortKey="Pooley, Ka" uniqKey="Pooley K">KA Pooley</name></author><author><name sortKey="Luben, R" uniqKey="Luben R">R Luben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, W" uniqKey="Zheng W">W Zheng</name></author><author><name sortKey="Long, J" uniqKey="Long J">J Long</name></author><author><name sortKey="Gao, Yt" uniqKey="Gao Y">YT Gao</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name></author><author><name sortKey="Xiang, Yb" uniqKey="Xiang Y">YB Xiang</name></author><author><name sortKey="Wen, W" uniqKey="Wen W">W Wen</name></author><author><name sortKey="Levy, S" uniqKey="Levy S">S Levy</name></author><author><name sortKey="Deming, Sl" uniqKey="Deming S">SL Deming</name></author><author><name sortKey="Haines, Jl" uniqKey="Haines J">JL Haines</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, G" uniqKey="Thomas G">G Thomas</name></author><author><name sortKey="Jacobs, Kb" uniqKey="Jacobs K">KB Jacobs</name></author><author><name sortKey="Kraft, P" uniqKey="Kraft P">P Kraft</name></author><author><name sortKey="Yeager, M" uniqKey="Yeager M">M Yeager</name></author><author><name sortKey="Wacholder, S" uniqKey="Wacholder S">S Wacholder</name></author><author><name sortKey="Cox, Dg" uniqKey="Cox D">DG Cox</name></author><author><name sortKey="Hankinson, Se" uniqKey="Hankinson S">SE Hankinson</name></author><author><name sortKey="Hutchinson, A" uniqKey="Hutchinson A">A Hutchinson</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Yu, K" uniqKey="Yu K">K Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacey, Sn" uniqKey="Stacey S">SN Stacey</name></author><author><name sortKey="Manolescu, A" uniqKey="Manolescu A">A Manolescu</name></author><author><name sortKey="Sulem, P" uniqKey="Sulem P">P Sulem</name></author><author><name sortKey="Rafnar, T" uniqKey="Rafnar T">T Rafnar</name></author><author><name sortKey="Gudmundsson, J" uniqKey="Gudmundsson J">J Gudmundsson</name></author><author><name sortKey="Gudjonsson, Sa" uniqKey="Gudjonsson S">SA Gudjonsson</name></author><author><name sortKey="Masson, G" uniqKey="Masson G">G Masson</name></author><author><name sortKey="Jakobsdottir, M" uniqKey="Jakobsdottir M">M Jakobsdottir</name></author><author><name sortKey="Thorlacius, S" uniqKey="Thorlacius S">S Thorlacius</name></author><author><name sortKey="Helgason, A" uniqKey="Helgason A">A Helgason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michailidou, K" uniqKey="Michailidou K">K Michailidou</name></author><author><name sortKey="Hall, P" uniqKey="Hall P">P Hall</name></author><author><name sortKey="Gonzalez Neira, A" uniqKey="Gonzalez Neira A">A Gonzalez-Neira</name></author><author><name sortKey="Ghoussaini, M" uniqKey="Ghoussaini M">M Ghoussaini</name></author><author><name sortKey="Dennis, J" uniqKey="Dennis J">J Dennis</name></author><author><name sortKey="Milne, Rl" uniqKey="Milne R">RL Milne</name></author><author><name sortKey="Schmidt, Mk" uniqKey="Schmidt M">MK Schmidt</name></author><author><name sortKey="Chang Claude, J" uniqKey="Chang Claude J">J Chang-Claude</name></author><author><name sortKey="Bojesen, Se" uniqKey="Bojesen S">SE Bojesen</name></author><author><name sortKey="Bolla, Mk" uniqKey="Bolla M">MK Bolla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Closas, M" uniqKey="Garcia Closas M">M Garcia-Closas</name></author><author><name sortKey="Couch, Fj" uniqKey="Couch F">FJ Couch</name></author><author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name></author><author><name sortKey="Michailidou, K" uniqKey="Michailidou K">K Michailidou</name></author><author><name sortKey="Schmidt, Mk" uniqKey="Schmidt M">MK Schmidt</name></author><author><name sortKey="Brook, Mn" uniqKey="Brook M">MN Brook</name></author><author><name sortKey="Orr, N" uniqKey="Orr N">N Orr</name></author><author><name sortKey="Rhie, Sk" uniqKey="Rhie S">SK Rhie</name></author><author><name sortKey="Riboli, E" uniqKey="Riboli E">E Riboli</name></author><author><name sortKey="Feigelson, Hs" uniqKey="Feigelson H">HS Feigelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bojesen, Se" uniqKey="Bojesen S">SE Bojesen</name></author><author><name sortKey="Pooley, Ka" uniqKey="Pooley K">KA Pooley</name></author><author><name sortKey="Johnatty, Se" uniqKey="Johnatty S">SE Johnatty</name></author><author><name sortKey="Beesley, J" uniqKey="Beesley J">J Beesley</name></author><author><name sortKey="Michailidou, K" uniqKey="Michailidou K">K Michailidou</name></author><author><name sortKey="Tyrer, Jp" uniqKey="Tyrer J">JP Tyrer</name></author><author><name sortKey="Edwards, Sl" uniqKey="Edwards S">SL Edwards</name></author><author><name sortKey="Pickett, Ha" uniqKey="Pickett H">HA Pickett</name></author><author><name sortKey="Shen, Hc" uniqKey="Shen H">HC Shen</name></author><author><name sortKey="Smart, Ce" uniqKey="Smart C">CE Smart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corbex, M" uniqKey="Corbex M">M Corbex</name></author><author><name sortKey="Bouzbid, S" uniqKey="Bouzbid S">S Bouzbid</name></author><author><name sortKey="Boffetta, P" uniqKey="Boffetta P">P Boffetta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Mccarron, P" uniqKey="Mccarron P">P McCarron</name></author><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chouchane, L" uniqKey="Chouchane L">L Chouchane</name></author><author><name sortKey="Boussen, H" uniqKey="Boussen H">H Boussen</name></author><author><name sortKey="Sastry, Ks" uniqKey="Sastry K">KS Sastry</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mourali, N" uniqKey="Mourali N">N Mourali</name></author><author><name sortKey="Muenz, Lr" uniqKey="Muenz L">LR Muenz</name></author><author><name sortKey="Tabbane, F" uniqKey="Tabbane F">F Tabbane</name></author><author><name sortKey="Belhassen, S" uniqKey="Belhassen S">S Belhassen</name></author><author><name sortKey="Bahi, J" uniqKey="Bahi J">J Bahi</name></author><author><name sortKey="Levine, Ph" uniqKey="Levine P">PH Levine</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Auton, A" uniqKey="Auton A">A Auton</name></author><author><name sortKey="Brooks, Ld" uniqKey="Brooks L">LD Brooks</name></author><author><name sortKey="Durbin, Rm" uniqKey="Durbin R">RM Durbin</name></author><author><name sortKey="Garrison, Ep" uniqKey="Garrison E">EP Garrison</name></author><author><name sortKey="Kang, Hm" uniqKey="Kang H">HM Kang</name></author><author><name sortKey="Korbel, Jo" uniqKey="Korbel J">JO Korbel</name></author><author><name sortKey="Marchini, Jl" uniqKey="Marchini J">JL Marchini</name></author><author><name sortKey="Mccarthy, S" uniqKey="Mccarthy S">S McCarthy</name></author><author><name sortKey="Mcvean, Ga" uniqKey="Mcvean G">GA McVean</name></author><author><name sortKey="Abecasis, Gr" uniqKey="Abecasis G">GR Abecasis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stranger, Be" uniqKey="Stranger B">BE Stranger</name></author><author><name sortKey="Stahl, Ea" uniqKey="Stahl E">EA Stahl</name></author><author><name sortKey="Raj, T" uniqKey="Raj T">T Raj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freedman, Ml" uniqKey="Freedman M">ML Freedman</name></author><author><name sortKey="Monteiro, An" uniqKey="Monteiro A">AN Monteiro</name></author><author><name sortKey="Gayther, Sa" uniqKey="Gayther S">SA Gayther</name></author><author><name sortKey="Coetzee, Ga" uniqKey="Coetzee G">GA Coetzee</name></author><author><name sortKey="Risch, A" uniqKey="Risch A">A Risch</name></author><author><name sortKey="Plass, C" uniqKey="Plass C">C Plass</name></author><author><name sortKey="Casey, G" uniqKey="Casey G">G Casey</name></author><author><name sortKey="De Biasi, M" uniqKey="De Biasi M">M De Biasi</name></author><author><name sortKey="Carlson, C" uniqKey="Carlson C">C Carlson</name></author><author><name sortKey="Duggan, D" uniqKey="Duggan D">D Duggan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccarthy, Mi" uniqKey="Mccarthy M">MI McCarthy</name></author><author><name sortKey="Hirschhorn, Jn" uniqKey="Hirschhorn J">JN Hirschhorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teo, Yy" uniqKey="Teo Y">YY Teo</name></author><author><name sortKey="Small, Ks" uniqKey="Small K">KS Small</name></author><author><name sortKey="Kwiatkowski, Dp" uniqKey="Kwiatkowski D">DP Kwiatkowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maxwell, Kn" uniqKey="Maxwell K">KN Maxwell</name></author><author><name sortKey="Nathanson, Kl" uniqKey="Nathanson K">KL Nathanson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Edwards, Sl" uniqKey="Edwards S">SL Edwards</name></author><author><name sortKey="Beesley, J" uniqKey="Beesley J">J Beesley</name></author><author><name sortKey="French, Jd" uniqKey="French J">JD French</name></author><author><name sortKey="Dunning, Am" uniqKey="Dunning A">AM Dunning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Udler, Ms" uniqKey="Udler M">MS Udler</name></author><author><name sortKey="Meyer, Kb" uniqKey="Meyer K">KB Meyer</name></author><author><name sortKey="Pooley, Ka" uniqKey="Pooley K">KA Pooley</name></author><author><name sortKey="Karlins, E" uniqKey="Karlins E">E Karlins</name></author><author><name sortKey="Struewing, Jp" uniqKey="Struewing J">JP Struewing</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Doody, Dr" uniqKey="Doody D">DR Doody</name></author><author><name sortKey="Macarthur, S" uniqKey="Macarthur S">S MacArthur</name></author><author><name sortKey="Tyrer, J" uniqKey="Tyrer J">J Tyrer</name></author><author><name sortKey="Pharoah, Pd" uniqKey="Pharoah P">PD Pharoah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henn, Bm" uniqKey="Henn B">BM Henn</name></author><author><name sortKey="Botigue, Lr" uniqKey="Botigue L">LR Botigue</name></author><author><name sortKey="Gravel, S" uniqKey="Gravel S">S Gravel</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Brisbin, A" uniqKey="Brisbin A">A Brisbin</name></author><author><name sortKey="Byrnes, Jk" uniqKey="Byrnes J">JK Byrnes</name></author><author><name sortKey="Fadhlaoui Zid, K" uniqKey="Fadhlaoui Zid K">K Fadhlaoui-Zid</name></author><author><name sortKey="Zalloua, Pa" uniqKey="Zalloua P">PA Zalloua</name></author><author><name sortKey="Moreno Estrada, A" uniqKey="Moreno Estrada A">A Moreno-Estrada</name></author><author><name sortKey="Bertranpetit, J" uniqKey="Bertranpetit J">J Bertranpetit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Halim, N" uniqKey="Ben Halim N">N Ben Halim</name></author><author><name sortKey="Ben Alaya Bouafif, N" uniqKey="Ben Alaya Bouafif N">N Ben Alaya Bouafif</name></author><author><name sortKey="Romdhane, L" uniqKey="Romdhane L">L Romdhane</name></author><author><name sortKey="Kefi Ben Atig, R" uniqKey="Kefi Ben Atig R">R Kefi Ben Atig</name></author><author><name sortKey="Chouchane, I" uniqKey="Chouchane I">I Chouchane</name></author><author><name sortKey="Bouyacoub, Y" uniqKey="Bouyacoub Y">Y Bouyacoub</name></author><author><name sortKey="Arfa, I" uniqKey="Arfa I">I Arfa</name></author><author><name sortKey="Cherif, W" uniqKey="Cherif W">W Cherif</name></author><author><name sortKey="Nouira, S" uniqKey="Nouira S">S Nouira</name></author><author><name sortKey="Talmoudi, F" uniqKey="Talmoudi F">F Talmoudi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Troudi, W" uniqKey="Troudi W">W Troudi</name></author><author><name sortKey="Uhrhammer, N" uniqKey="Uhrhammer N">N Uhrhammer</name></author><author><name sortKey="Sibille, C" uniqKey="Sibille C">C Sibille</name></author><author><name sortKey="Dahan, C" uniqKey="Dahan C">C Dahan</name></author><author><name sortKey="Mahfoudh, W" uniqKey="Mahfoudh W">W Mahfoudh</name></author><author><name sortKey="Bouchlaka Souissi, C" uniqKey="Bouchlaka Souissi C">C Bouchlaka Souissi</name></author><author><name sortKey="Jalabert, T" uniqKey="Jalabert T">T Jalabert</name></author><author><name sortKey="Chouchane, L" uniqKey="Chouchane L">L Chouchane</name></author><author><name sortKey="Bignon, Yj" uniqKey="Bignon Y">YJ Bignon</name></author><author><name sortKey="Ben Ayed, F" uniqKey="Ben Ayed F">F Ben Ayed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fourati, A" uniqKey="Fourati A">A Fourati</name></author><author><name sortKey="Louchez, Mm" uniqKey="Louchez M">MM Louchez</name></author><author><name sortKey="Fournier, J" uniqKey="Fournier J">J Fournier</name></author><author><name sortKey="Gamoudi, A" uniqKey="Gamoudi A">A Gamoudi</name></author><author><name sortKey="Rahal, K" uniqKey="Rahal K">K Rahal</name></author><author><name sortKey="El May, Mv" uniqKey="El May M">MV El May</name></author><author><name sortKey="El May, A" uniqKey="El May A">A El May</name></author><author><name sortKey="Revillion, F" uniqKey="Revillion F">F Revillion</name></author><author><name sortKey="Peyrat, Jp" uniqKey="Peyrat J">JP Peyrat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shan, J" uniqKey="Shan J">J Shan</name></author><author><name sortKey="Mahfoudh, W" uniqKey="Mahfoudh W">W Mahfoudh</name></author><author><name sortKey="Dsouza, Sp" uniqKey="Dsouza S">SP Dsouza</name></author><author><name sortKey="Hassen, E" uniqKey="Hassen E">E Hassen</name></author><author><name sortKey="Bouaouina, N" uniqKey="Bouaouina N">N Bouaouina</name></author><author><name sortKey="Abdelhak, S" uniqKey="Abdelhak S">S Abdelhak</name></author><author><name sortKey="Benhadjayed, A" uniqKey="Benhadjayed A">A Benhadjayed</name></author><author><name sortKey="Memmi, H" uniqKey="Memmi H">H Memmi</name></author><author><name sortKey="Mathew, Ra" uniqKey="Mathew R">RA Mathew</name></author><author><name sortKey="Aigha, Ii" uniqKey="Aigha I">II Aigha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Sa" uniqKey="Miller S">SA Miller</name></author><author><name sortKey="Dykes, Dd" uniqKey="Dykes D">DD Dykes</name></author><author><name sortKey="Polesky, Hf" uniqKey="Polesky H">HF Polesky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scharpf, Rb" uniqKey="Scharpf R">RB Scharpf</name></author><author><name sortKey="Irizarry, Ra" uniqKey="Irizarry R">RA Irizarry</name></author><author><name sortKey="Ritchie, Me" uniqKey="Ritchie M">ME Ritchie</name></author><author><name sortKey="Carvalho, B" uniqKey="Carvalho B">B Carvalho</name></author><author><name sortKey="Ruczinski, I" uniqKey="Ruczinski I">I Ruczinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez, Jr" uniqKey="Gonzalez J">JR Gonzalez</name></author><author><name sortKey="Armengol, L" uniqKey="Armengol L">L Armengol</name></author><author><name sortKey="Sole, X" uniqKey="Sole X">X Sole</name></author><author><name sortKey="Guino, E" uniqKey="Guino E">E Guino</name></author><author><name sortKey="Mercader, Jm" uniqKey="Mercader J">JM Mercader</name></author><author><name sortKey="Estivill, X" uniqKey="Estivill X">X Estivill</name></author><author><name sortKey="Moreno, V" uniqKey="Moreno V">V Moreno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barrett, Jc" uniqKey="Barrett J">JC Barrett</name></author><author><name sortKey="Fry, B" uniqKey="Fry B">B Fry</name></author><author><name sortKey="Maller, J" uniqKey="Maller J">J Maller</name></author><author><name sortKey="Daly, Mj" uniqKey="Daly M">MJ Daly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gabriel, Sb" uniqKey="Gabriel S">SB Gabriel</name></author><author><name sortKey="Schaffner, Sf" uniqKey="Schaffner S">SF Schaffner</name></author><author><name sortKey="Nguyen, H" uniqKey="Nguyen H">H Nguyen</name></author><author><name sortKey="Moore, Jm" uniqKey="Moore J">JM Moore</name></author><author><name sortKey="Roy, J" uniqKey="Roy J">J Roy</name></author><author><name sortKey="Blumenstiel, B" uniqKey="Blumenstiel B">B Blumenstiel</name></author><author><name sortKey="Higgins, J" uniqKey="Higgins J">J Higgins</name></author><author><name sortKey="Defelice, M" uniqKey="Defelice M">M DeFelice</name></author><author><name sortKey="Lochner, A" uniqKey="Lochner A">A Lochner</name></author><author><name sortKey="Faggart, M" uniqKey="Faggart M">M Faggart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stephens, M" uniqKey="Stephens M">M Stephens</name></author><author><name sortKey="Smith, Nj" uniqKey="Smith N">NJ Smith</name></author><author><name sortKey="Donnelly, P" uniqKey="Donnelly P">P Donnelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tavtigian, Sv" uniqKey="Tavtigian S">SV Tavtigian</name></author><author><name sortKey="Greenblatt, Ms" uniqKey="Greenblatt M">MS Greenblatt</name></author><author><name sortKey="Lesueur, F" uniqKey="Lesueur F">F Lesueur</name></author><author><name sortKey="Byrnes, Gb" uniqKey="Byrnes G">GB Byrnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Pc" uniqKey="Ng P">PC Ng</name></author><author><name sortKey="Henikoff, S" uniqKey="Henikoff S">S Henikoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyle, Ap" uniqKey="Boyle A">AP Boyle</name></author><author><name sortKey="Hong, El" uniqKey="Hong E">EL Hong</name></author><author><name sortKey="Hariharan, M" uniqKey="Hariharan M">M Hariharan</name></author><author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y Cheng</name></author><author><name sortKey="Schaub, Ma" uniqKey="Schaub M">MA Schaub</name></author><author><name sortKey="Kasowski, M" uniqKey="Kasowski M">M Kasowski</name></author><author><name sortKey="Karczewski, Kj" uniqKey="Karczewski K">KJ Karczewski</name></author><author><name sortKey="Park, J" uniqKey="Park J">J Park</name></author><author><name sortKey="Hitz, Bc" uniqKey="Hitz B">BC Hitz</name></author><author><name sortKey="Weng, S" uniqKey="Weng S">S Weng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Tp" uniqKey="Yang T">TP Yang</name></author><author><name sortKey="Beazley, C" uniqKey="Beazley C">C Beazley</name></author><author><name sortKey="Montgomery, Sb" uniqKey="Montgomery S">SB Montgomery</name></author><author><name sortKey="Dimas, As" uniqKey="Dimas A">AS Dimas</name></author><author><name sortKey="Gutierrez Arcelus, M" uniqKey="Gutierrez Arcelus M">M Gutierrez-Arcelus</name></author><author><name sortKey="Stranger, Be" uniqKey="Stranger B">BE Stranger</name></author><author><name sortKey="Deloukas, P" uniqKey="Deloukas P">P Deloukas</name></author><author><name sortKey="Dermitzakis, Et" uniqKey="Dermitzakis E">ET Dermitzakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I Soerjomataram</name></author><author><name sortKey="Dikshit, R" uniqKey="Dikshit R">R Dikshit</name></author><author><name sortKey="Eser, S" uniqKey="Eser S">S Eser</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Rebelo, M" uniqKey="Rebelo M">M Rebelo</name></author><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chalabi, N" uniqKey="Chalabi N">N Chalabi</name></author><author><name sortKey="Bernard Gallon, Dj" uniqKey="Bernard Gallon D">DJ Bernard-Gallon</name></author><author><name sortKey="Bignon, Yj" uniqKey="Bignon Y">YJ Bignon</name></author><author><name sortKey="Kwiatkowski, F" uniqKey="Kwiatkowski F">F Kwiatkowski</name></author><author><name sortKey="Agier, M" uniqKey="Agier M">M Agier</name></author><author><name sortKey="Vidal, V" uniqKey="Vidal V">V Vidal</name></author><author><name sortKey="Laplace Chabaud, V" uniqKey="Laplace Chabaud V">V Laplace-Chabaud</name></author><author><name sortKey="Sylvain Vidal, V" uniqKey="Sylvain Vidal V">V Sylvain-Vidal</name></author><author><name sortKey="Bertholet, V" uniqKey="Bertholet V">V Bertholet</name></author><author><name sortKey="De Longueville, F" uniqKey="De Longueville F">F De Longueville</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Medimegh, I" uniqKey="Medimegh I">I Medimegh</name></author><author><name sortKey="Troudi, W" uniqKey="Troudi W">W Troudi</name></author><author><name sortKey="Omrane, I" uniqKey="Omrane I">I Omrane</name></author><author><name sortKey="Ayari, H" uniqKey="Ayari H">H Ayari</name></author><author><name sortKey="Uhrhummer, N" uniqKey="Uhrhummer N">N Uhrhummer</name></author><author><name sortKey="Majoul, H" uniqKey="Majoul H">H Majoul</name></author><author><name sortKey="Benayed, F" uniqKey="Benayed F">F Benayed</name></author><author><name sortKey="Mezlini, A" uniqKey="Mezlini A">A Mezlini</name></author><author><name sortKey="Bignon, Yj" uniqKey="Bignon Y">YJ Bignon</name></author><author><name sortKey="Sibille, C" uniqKey="Sibille C">C Sibille</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahfoudh, W" uniqKey="Mahfoudh W">W Mahfoudh</name></author><author><name sortKey="Bouaouina, N" uniqKey="Bouaouina N">N Bouaouina</name></author><author><name sortKey="Ahmed, Sb" uniqKey="Ahmed S">SB Ahmed</name></author><author><name sortKey="Gabbouj, S" uniqKey="Gabbouj S">S 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Uhrhammer</name></author><author><name sortKey="Privat, M" uniqKey="Privat M">M Privat</name></author><author><name sortKey="Mezlini, A" uniqKey="Mezlini A">A Mezlini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kefi, R" uniqKey="Kefi R">R Kefi</name></author><author><name sortKey="Hsouna, S" uniqKey="Hsouna S">S Hsouna</name></author><author><name sortKey="Ben Halim, N" uniqKey="Ben Halim N">N Ben Halim</name></author><author><name sortKey="Lasram, K" uniqKey="Lasram K">K Lasram</name></author><author><name sortKey="Romdhane, L" uniqKey="Romdhane L">L Romdhane</name></author><author><name sortKey="Messai, H" uniqKey="Messai H">H Messai</name></author><author><name sortKey="Abdelhak, S" uniqKey="Abdelhak S">S Abdelhak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Halim, N" uniqKey="Ben Halim N">N Ben Halim</name></author><author><name sortKey="Dorboz, I" uniqKey="Dorboz I">I Dorboz</name></author><author><name sortKey="Kefi, R" uniqKey="Kefi R">R Kefi</name></author><author><name sortKey="Kharrat, N" uniqKey="Kharrat N">N Kharrat</name></author><author><name sortKey="Eymard Pierre, E" uniqKey="Eymard Pierre E">E Eymard-Pierre</name></author><author><name sortKey="Nagara, M" uniqKey="Nagara M">M Nagara</name></author><author><name sortKey="Romdhane, L" uniqKey="Romdhane L">L Romdhane</name></author><author><name sortKey="Ben Alaya Bouafif, N" uniqKey="Ben Alaya Bouafif N">N Ben Alaya-Bouafif</name></author><author><name sortKey="Rebai, A" uniqKey="Rebai A">A Rebai</name></author><author><name sortKey="Miladi, N" uniqKey="Miladi N">N Miladi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ennafaa, H" uniqKey="Ennafaa H">H Ennafaa</name></author><author><name sortKey="Fregel, R" uniqKey="Fregel R">R Fregel</name></author><author><name sortKey="Khodjet El Khil, H" uniqKey="Khodjet El Khil H">H 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Benammar-Elgaaied</name></author><author><name sortKey="Comas, D" uniqKey="Comas D">D Comas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cherni, L" uniqKey="Cherni L">L Cherni</name></author><author><name sortKey="Fernandes, V" uniqKey="Fernandes V">V Fernandes</name></author><author><name sortKey="Pereira, Jb" uniqKey="Pereira J">JB Pereira</name></author><author><name sortKey="Costa, Md" uniqKey="Costa M">MD Costa</name></author><author><name sortKey="Goios, A" uniqKey="Goios A">A Goios</name></author><author><name sortKey="Frigi, S" uniqKey="Frigi S">S Frigi</name></author><author><name sortKey="Yacoubi Loueslati, B" uniqKey="Yacoubi Loueslati B">B Yacoubi-Loueslati</name></author><author><name sortKey="Amor, Mb" uniqKey="Amor M">MB Amor</name></author><author><name sortKey="Slama, A" uniqKey="Slama A">A Slama</name></author><author><name sortKey="Amorim, A" uniqKey="Amorim A">A Amorim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruiz Narvaez, Ea" uniqKey="Ruiz Narvaez E">EA Ruiz-Narvaez</name></author><author><name sortKey="Rosenberg, L" uniqKey="Rosenberg L">L Rosenberg</name></author><author><name sortKey="Yao, S" uniqKey="Yao S">S Yao</name></author><author><name sortKey="Rotimi, Cn" uniqKey="Rotimi C">CN Rotimi</name></author><author><name sortKey="Cupples, Al" uniqKey="Cupples A">AL Cupples</name></author><author><name sortKey="Bandera, Ev" uniqKey="Bandera E">EV Bandera</name></author><author><name sortKey="Ambrosone, Cb" uniqKey="Ambrosone C">CB Ambrosone</name></author><author><name sortKey="Adams Campbell, Ll" uniqKey="Adams Campbell L">LL Adams-Campbell</name></author><author><name sortKey="Palmer, Jr" uniqKey="Palmer J">JR Palmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Long, J" uniqKey="Long J">J Long</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang 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uniqKey="Simard J">J Simard</name></author><author><name sortKey="Sinnett, D" uniqKey="Sinnett D">D Sinnett</name></author><author><name sortKey="Hamdi, Y" uniqKey="Hamdi Y">Y Hamdi</name></author><author><name sortKey="Soucy, P" uniqKey="Soucy P">P Soucy</name></author><author><name sortKey="Ouimet, M" uniqKey="Ouimet M">M Ouimet</name></author><author><name sortKey="Barjhoux, L" uniqKey="Barjhoux L">L Barjhoux</name></author><author><name sortKey="Verny Pierre, C" uniqKey="Verny Pierre C">C Verny-Pierre</name></author><author><name sortKey="Mcguffog, L" uniqKey="Mcguffog L">L McGuffog</name></author><author><name sortKey="Healey, S" uniqKey="Healey S">S Healey</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Qatar</li><li>Tunisie</li></country></list><tree><noCountry><name sortKey="Abdelhak, Sonia" sort="Abdelhak, Sonia" uniqKey="Abdelhak S" first="Sonia" last="Abdelhak">Sonia Abdelhak</name><name sortKey="Ben Rekaya, Mariem" sort="Ben Rekaya, Mariem" uniqKey="Ben Rekaya M" first="Mariem" last="Ben Rekaya">Mariem Ben Rekaya</name><name sortKey="Boubaker, Mohamed Samir" sort="Boubaker, Mohamed Samir" uniqKey="Boubaker M" first="Mohamed Samir" last="Boubaker">Mohamed Samir Boubaker</name><name sortKey="Hamdi, Yosr" sort="Hamdi, Yosr" uniqKey="Hamdi Y" first="Yosr" last="Hamdi">Yosr Hamdi</name><name sortKey="Messaoud, Olfa" sort="Messaoud, Olfa" uniqKey="Messaoud O" first="Olfa" last="Messaoud">Olfa Messaoud</name><name sortKey="Nagara, Majdi" sort="Nagara, Majdi" uniqKey="Nagara M" first="Majdi" last="Nagara">Majdi Nagara</name></noCountry><country name="Qatar"><noRegion><name sortKey="Jingxuan, Shan" sort="Jingxuan, Shan" uniqKey="Jingxuan S" first="Shan" last="Jingxuan">Shan Jingxuan</name></noRegion><name sortKey="Chouchane, Lotfi" sort="Chouchane, Lotfi" uniqKey="Chouchane L" first="Lotfi" last="Chouchane">Lotfi Chouchane</name></country><country name="Tunisie"><noRegion><name sortKey="Benammar Elgaaied, Amel" sort="Benammar Elgaaied, Amel" uniqKey="Benammar Elgaaied A" first="Amel" last="Benammar Elgaaied">Amel Benammar Elgaaied</name></noRegion><name sortKey="Boussen, Hamouda" sort="Boussen, Hamouda" uniqKey="Boussen H" first="Hamouda" last="Boussen">Hamouda Boussen</name><name sortKey="Mrad, Ridha" sort="Mrad, Ridha" uniqKey="Mrad R" first="Ridha" last="Mrad">Ridha Mrad</name><name sortKey="Romdhane, Lilia" sort="Romdhane, Lilia" uniqKey="Romdhane L" first="Lilia" last="Romdhane">Lilia Romdhane</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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